Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.

@article{Liu2010ContributionOM,
  title={Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.},
  author={Yongjian Liu and Xiaoyu Xiang and Xiaoying Zhuang and Shuangyin Zhang and Cunren Liu and Ziqiang Zack Cheng and Sue Michalek and William E. Grizzle and Hong Gang Zhang},
  journal={The American journal of pathology},
  year={2010},
  volume={176 5},
  pages={
          2490-9
        }
}
In this study we observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung. Tumor metastasis correlated significantly with an increase in recruitment of more Myeloid-derived suppressor cells (MDSCs) in the lung of C57BL/6j (B6) mice pretreated with tumor exosomes. These effects were blunted when MyD88 knockout (KO) mice were pretreated with tumor exosomes. MDSCs induced by tumor exosomes and isolated from wild-type B6 mice also more… CONTINUE READING
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