Contribution of MxB Oligomerization to HIV-1 Capsid Binding and Restriction

@article{Buffone2015ContributionOM,
  title={Contribution of MxB Oligomerization to HIV-1 Capsid Binding and Restriction},
  author={Cindy Buffone and Bianca Schulte and S. Opp and F. Diaz-Griffero},
  journal={Journal of Virology},
  year={2015},
  volume={89},
  pages={3285 - 3294}
}
ABSTRACT The alpha interferon (IFN-α)-inducible restriction factor myxovirus B (MxB) blocks HIV-1 infection after reverse transcription but prior to integration. MxB binds to the HIV-1 core, which is composed of capsid protein, and this interaction leads to inhibition of the uncoating process of HIV-1. Previous studies suggested that HIV-1 restriction by MxB requires binding to capsid. This work tests the hypothesis that MxB oligomerization is important for the ability of MxB to bind to the HIV… Expand
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TLDR
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TLDR
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TLDR
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