Contribution of MLPA to routine diagnostic testing of recurrent genomic aberrations in chronic lymphocytic leukemia.

@article{Vronse2013ContributionOM,
  title={Contribution of MLPA to routine diagnostic testing of recurrent genomic aberrations in chronic lymphocytic leukemia.},
  author={Lauren V{\'e}ron{\`e}se and Olivier Tournilhac and Patricia Combes and Nolwen Pri{\'e} and El{\'e}onore Pierre-Eymard and Romain Gui{\'e}ze and Richard Veyrat-Masson and J O Bay and Philippe Vago and Andre{\"i} Tchirkov},
  journal={Cancer genetics},
  year={2013},
  volume={206 1-2},
  pages={19-25}
}
To better define the place of multiplex ligation-dependent probe amplification (MLPA) in routine cytogenetic diagnosis in chronic lymphocytic leukemia (CLL), we compared MLPA and fluorescence in situ hybridization (iFISH) data obtained in 77 CLL patients. Although MLPA detected most recurrent copy number genomic aberrations (90.9%), false-negative results were found in cases with small-size abnormal clones and false-positive MLPA findings resulting from point mutations (TP53) or an apparent… CONTINUE READING

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