Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects.

@article{Benini2004ContributionOM,
  title={Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects.},
  author={Stefania Benini and Maria Cristina Manara and Vanessa Cerisano and Stefania Perdichizzi and Rosaria Strammiello and Massimo Serra and Piero Picci and Katia Scotlandi},
  journal={International journal of cancer},
  year={2004},
  volume={108 3},
  pages={358-66}
}
Insulin-like growth factor receptor I (IGF-I)-mediated circuit is a major autocrine loop for Ewing's sarcoma (ES) cells and appears to be particularly important in the pathogenesis of this tumor. In this study, we analyzed the contribution of the 2 major pathways of the intracellular IGF-IR signaling cascade to the overall effects elicited by IGF-I in ES. Both the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3-K) signaling pathways appeared to be constitutively… CONTINUE READING
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