Contribution of Long-QT Syndrome Genetic Variants in Sudden Infant Death Syndrome

  title={Contribution of Long-QT Syndrome Genetic Variants in Sudden Infant Death Syndrome},
  author={G. Millat and B. Kugener and P. Chevalier and M. Chahine and H. Huang and D. Malicier and C. Rodriguez-Lafrasse and R. Rousson},
  journal={Pediatric Cardiology},
  • G. Millat, B. Kugener, +5 authors R. Rousson
  • Published 2009
  • Medicine
  • Pediatric Cardiology
  • A cohort of 52 French unrelated infant cases who died unexpectedly before they reached 12 months of age was blindly investigated to better quantify the contribution of long-QT syndrome (LQTS) genetic variants in French cases of sudden infant death syndrome (SIDS). After a standardized autopsy protocol, a blinded molecular screening of the KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 genes was performed on each case. These postmortem investigations enabled us to reclassify 18 as non-SIDS cases, 32 as… CONTINUE READING
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