Contribution of Long-QT Syndrome Genetic Variants in Sudden Infant Death Syndrome

@article{Millat2009ContributionOL,
  title={Contribution of Long-QT Syndrome Genetic Variants in Sudden Infant Death Syndrome},
  author={G. Millat and B. Kugener and P. Chevalier and M. Chahine and H. Huang and D. Malicier and C. Rodriguez-Lafrasse and R. Rousson},
  journal={Pediatric Cardiology},
  year={2009},
  volume={30},
  pages={502-509}
}
  • G. Millat, B. Kugener, +5 authors R. Rousson
  • Published 2009
  • Medicine
  • Pediatric Cardiology
  • A cohort of 52 French unrelated infant cases who died unexpectedly before they reached 12 months of age was blindly investigated to better quantify the contribution of long-QT syndrome (LQTS) genetic variants in French cases of sudden infant death syndrome (SIDS). After a standardized autopsy protocol, a blinded molecular screening of the KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 genes was performed on each case. These postmortem investigations enabled us to reclassify 18 as non-SIDS cases, 32 as… CONTINUE READING
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    References

    SHOWING 1-10 OF 41 REFERENCES
    Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome
    • 512
    • Highly Influential
    Sudden infant death syndrome and long QT syndrome: an epidemiological and genetic study
    • 56
    Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome.
    • 444
    • Highly Influential
    • PDF
    De Novo Mutation in the SCN5A Gene Associated With Early Onset of Sudden Infant Death
    • 176
    Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3.
    • 236
    Molecular diagnosis in a child with sudden infant death syndrome
    • 163
    Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome
    • 78
    Potential Role of QT Interval Prolongation in Sudden Infant Death Syndrome
    • 128
    • PDF
    Sudden Infant Death Syndrome: Review of implicated genetic factors
    • 125