Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats.

@article{Stott2015ContributionOK,
  title={Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats.},
  author={Jennifer B. Stott and Vincenzo Barrese and Thomas A Jepps and Emma V. Leighton and Iain Andrew Greenwood},
  journal={Hypertension},
  year={2015},
  volume={65 3},
  pages={676-82}
}
The Kv7 family of voltage-gated potassium channels are expressed within the vasculature where they are key regulators of vascular tone and mediate cAMP-linked endogenous vasodilator responses, a pathway that is compromised in hypertension. However, the role of Kv7 channels in non-cAMP-linked vasodilator pathways has not been investigated. Natriuretic peptides are potent vasodilators, which operate primarily through the activation of a cGMP-dependent signaling pathway. This study investigated… CONTINUE READING
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