Contribution of Interaction between Nitric Oxide and Cyclooxygenases to the Production of Prostaglandins in Carrageenan-induced Inflammation
@article{Toriyabe2004ContributionOI, title={Contribution of Interaction between Nitric Oxide and Cyclooxygenases to the Production of Prostaglandins in Carrageenan-induced Inflammation}, author={Masaki Toriyabe and Keiichi Omote and Tomoyuki Kawamata and Akiyoshi Namiki}, journal={Anesthesiology}, year={2004}, volume={101}, pages={983-990} }
Background:Nitric oxide (NO) and prostaglandins (PGs) are crucial mediators contributing to generation of inflammatory responses and pain. This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation. Methods:A microdialysis probe was implanted subcutaneously into the skin of hind paws of rats. The concentrations of NO metabolites, PGE2, and 6-keto-PGF1&agr; (metabolite of…
67 Citations
Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni.
- BiologyEuropean journal of pharmacology
- 2008
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study.
- Biology, MedicineEuropean journal of pharmacology
- 2007
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
- BiologyProstaglandins, leukotrienes, and essential fatty acids
- 2008
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors.
- BiologyPhysiological reviews
- 2012
This review aims to give an account of the excitatory and sensitizing actions of inflammatory mediators including bradykinin, prostaglandins, thromboxanes, leukotrienes, platelet-activating factor, and nitric oxide on nociceptive primary afferent neurons.
Eicosanoids in inflammation and cancer: the role of COX-2
- Biology, MedicineExpert review of clinical immunology
- 2009
The cardiac side effects of some of the coxibs have limited their application in treating various inflammatory disorders and warrant the development of COX-2 inhibitors without side effects, so a review will focus on the role of COx-2 in inflammation and cancer.
Synergistic anti-inflammatory interaction between meloxicam and aminoguanidine hydrochloride in carrageenan-induced acute inflammation in rats.
- Biology, ChemistryLife sciences
- 2006
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
- Biology, MedicineEuropean journal of pharmacology
- 2017
Preoptic nitric oxide attenuates endotoxic fever in guinea pigs by inhibiting the POA release of norepinephrine.
- Biology, MedicineAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2007
It is concluded that the antipyretic activity of NO derives from its inhibitory modulation of the LPS-induced release of POA NE, which implicate free radicals in POA PGE(2) production and raise questions about its role as a central LPS fever mediator.
The anti-inflammatory effects of N-methyl-(2S,4R)-trans-4-hydroxy-l-proline from Syderoxylon obtusifolium are related to its inhibition of TNF-alpha and inflammatory enzymes.
- Medicine, BiologyPhytomedicine : international journal of phytotherapy and phytopharmacology
- 2017
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate.
- BiologyChemico-biological interactions
- 2013
References
SHOWING 1-10 OF 38 REFERENCES
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.
- BiologyThe Journal of clinical investigation
- 1995
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide…
Pharmacological analysis of cyclooxygenase-1 in inflammation.
- Medicine, BiologyProceedings of the National Academy of Sciences of the United States of America
- 1998
The results suggest that, in addition to the role of peripherally produced PGs, there is a critical, centrally mediated neurological component to inflammatory pain that is mediated at least in part by COX-2.
Nitric oxide activates cyclooxygenase enzymes.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1993
It is demonstrated that NO enhances COX activity through a mechanism independent of cGMP and suggested that, in conditions in which both the NOS and COX systems are present, there is an NO-mediated increase in the production of proinflammatory prostaglandins that may result in an exacerbated inflammatory response.
Effects of nitric oxide and nitric oxide‐derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis
- BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 1999
This study has shown that removal of O2·− from RAW 267.4 cells that produce NO· and PGHS inhibits prostaglandin biosynthesis to the same extent as NOS inhibitors.
Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation
- MedicineBritish journal of pharmacology
- 1996
The results suggest that the NO produced by cNOS is involved in the development of inflammation at early time points following carrageenan administration and that No2−/NO3− or PGE2 production in the paw exudate is involvedin the maintenance of the inflammatory response at later time points.
Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1999
The results indicate that PGE2 and NO may play in vivo mutual modulatory roles in the inflammatory response caused by zymosan injection into the mouse air pouch, a suitable model to study drugs acting on those pathways.
Role of Prostaglandin Receptor EP1 in the Spinal Dorsal Horn in Carrageenan-induced Inflammatory Pain
- Biology, MedicineAnesthesiology
- 2002
It seems that some of the mechanisms underlying inflammation-induced plastic changes are mediated by time-dependent increase in PGE2 concentration, activation of EP1 receptors, and increase in [Ca2+]i in the spinal dorsal horn.
Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.
- Biology, MedicineThe Journal of clinical investigation
- 1996
It is suggested that COX-2 plays a prominent role in the inflammation associated with adjuvant arthritis and that COx-2 derived PGs upregulate CO X-2 and IL-6 expression at inflammatory sites.
Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages.
- BiologyJournal of immunology
- 1997
Results provide evidence that NO participates in PG production by negative regulation of Cox-2 expression, and addition of NO donors reversed the effects of L-NMMA, confirming the role of NO on Cox-1 expression.