Contribution of Interaction between Nitric Oxide and Cyclooxygenases to the Production of Prostaglandins in Carrageenan-induced Inflammation

@article{Toriyabe2004ContributionOI,
  title={Contribution of Interaction between Nitric Oxide and Cyclooxygenases to the Production of Prostaglandins in Carrageenan-induced Inflammation},
  author={Masaki Toriyabe and Keiichi Omote and Tomoyuki Kawamata and Akiyoshi Namiki},
  journal={Anesthesiology},
  year={2004},
  volume={101},
  pages={983-990}
}
Background:Nitric oxide (NO) and prostaglandins (PGs) are crucial mediators contributing to generation of inflammatory responses and pain. This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation. Methods:A microdialysis probe was implanted subcutaneously into the skin of hind paws of rats. The concentrations of NO metabolites, PGE2, and 6-keto-PGF1&agr; (metabolite of… 

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