Contribution of Fas ligand to T cell-mediated hepatic injury in mice.

Abstract

BACKGROUND & AIMS Fas has been implicated in liver damage. The aim of this study was to investigate the role of its ligand to induce hepatocyte death and liver damage in T cell-dependent hepatitis. METHODS Fas ligand-mediated lysis of primary hepatocytes from C57BL/6 wild-type, Fas ligand-deficient gld, and Fas-deficient lpr mice and concanavalin A… (More)

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