Contribution of Environment and Genetics to Pancreatic Cancer Susceptibility

  title={Contribution of Environment and Genetics to Pancreatic Cancer Susceptibility},
  author={Barbara A Hocevar and Lisa M. Kamendulis and Xinzhu Pu and Susan M. Perkins and Zheng-yu Wang and Erica L. Johnston and John M. Dewitt and Lang Li and Patrick J. Loehrer and James E Klaunig and Elena Gabriela Chiorean},
  booktitle={PloS one},
Several risk factors have been identified as potential contributors to pancreatic cancer development, including environmental and lifestyle factors, such as smoking, drinking and diet, and medical conditions such as diabetes and pancreatitis, all of which generate oxidative stress and DNA damage. Oxidative stress status can be modified by environmental factors and also by an individual's unique genetic makeup. Here we examined the contribution of environment and genetics to an individual's… CONTINUE READING
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