Contribution of Efa1/LifA to the adherence of enteropathogenic Escherichia coli to epithelial cells.

@article{Badea2003ContributionOE,
  title={Contribution of Efa1/LifA to the adherence of enteropathogenic Escherichia coli to epithelial cells.},
  author={Luminita Badea and Stephen William Doughty and Larissa Nicholls and Joan Sloan and Roy M Robins-Browne and Elizabeth L Hartland},
  journal={Microbial pathogenesis},
  year={2003},
  volume={34 5},
  pages={
          205-15
        }
}
Enteropathogenic E. coli(EPEC) is an important diarrhoeal pathogen that induces characteristic lesions on the host intestine termed attaching and effacing (A/E) lesions. In this study we have examined the contribution of a large gene, efa1, which is present in all A/E pathogens, to the adherence phenotype of EPEC. An efa- derivative of EPEC JPN15 was constructed and this mutant was significantly less adherent to epithelial cells than the parent strain. The JPN15 efa- derivative was FAS-positive… CONTINUE READING
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