Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

Abstract

The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand… (More)
DOI: 10.1371/journal.ppat.1001036

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