Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate

@article{Lu2011ContributionOC,
  title={Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate},
  author={You-li Lu and Narisu Bao and Gereltu Borjihan and Yanling Ma and Miaomiao Hu and Chen Yu and Shuijun Li and Jingying Jia and Ding Yang and Yi-ping Wang},
  journal={Drug Metabolism and Disposition},
  year={2011},
  volume={39},
  pages={796 - 802}
}
Ethyl piperate is an effective lipid-lowering drug candidate synthesized from piperine. However, its pharmacokinetic characteristics and oral absorption process remain unclear. A liquid chromatography-tandem mass spectrometry method was applied to determine the oral bioavailability of ethyl piperate. Simulated gastrointestinal pH conditions and intestinal washings were prepared to investigate their contributions to the loss of ethyl piperate. Hydrolysis by carboxylesterase (CES) was evaluated… 
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