Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney.

@article{Yamaguchi2002ContributionOC,
  title={Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney.},
  author={Yoshitaka Yamaguchi and Shirou Kirita and Hiroshi Hasegawa and Junko Aoyama and Susumu Imaoka and Sachiko Minamiyama and Yoshihiko Funae and Takahiko Baba and Takashi Matsubara},
  journal={Drug metabolism and pharmacokinetics},
  year={2002},
  volume={17 2},
  pages={109-16}
}
20-Hydroxyeicosatetraenoic acid (20-HETE) has been shown to be an arachidonic acid metabolite of the cytochrome P450 (CYP) enzymes belonging to the CYP4A subfamily and is a predominant regulator of renal vascular tone and tubular ion reabsorption in rat kidney. CYP4A8 is one of the CYP4A enzymes expressed in rat kidney, but its contribution to 20-HETE formation has not been assessed. In order to clarify that the role of CYP4A8, we have developed bacterial expression systems for the expression… CONTINUE READING
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