Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes.

@article{Hijazi2002ContributionOC,
  title={Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes.},
  author={Y. Hijazi and R. Boulieu},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 7},
  pages={
          853-8
        }
}
  • Y. Hijazi, R. Boulieu
  • Published 2002
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported. Ketamine is N-demethylated by liver microsomal cytochrome P450 into norketamine. The identification of the enzymes responsible for ketamine metabolism is of great importance in clinical practice. In the present study, we investigated the metabolism of ketamine in human liver microsomes at clinically relevant… CONTINUE READING
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