Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism

  title={Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism},
  author={Danuta Ligocka and Dominique Lison and Vincent Haufroid},
  journal={Archives of Toxicology},
The involvement of cytochrome P450 2E1 (CYP2E1) in the metabolism of N-methyl-2-pyrrolidone (NMP) was studied with three experimental approaches: in the rat, in vitro in human microsomes, and in human volunteers. NMP was administered dermally (40 mg/kg) to OFA rats to examine the influence of CYP2E1 inhibition (5 mg/kg diethyldithiocarbamate, DETC, 30 min… CONTINUE READING