Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.

@article{Edwards1994ContributionOC,
  title={Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.},
  author={Robert J. Edwards and Bryan P. Murray and Stephen Murray and Thomas Gerhard Schulz and Diether Neubert and Timothy W. Gant and Snorri Thorgeirsson and Alan R Boobis and Donald Davies},
  journal={Carcinogenesis},
  year={1994},
  volume={15 5},
  pages={829-36}
}
The activation of heterocyclic amines to mutagenic products by hepatic microsomal fractions from cynomolgus monkey, marmoset monkey and man was compared with the respective levels of cytochrome P450 enzymes CYP1A1 and CYP1A2. The rate of activation of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2… CONTINUE READING