Contribution of CD95 ligand-induced neutrophil infiltration to the bystander effect in p53 gene therapy for human cancer.

Abstract

Clinical trials of adenoviral p53 gene therapy provide the evidence that the bystander effect induced by the wild-type p53 gene transfer on adjacent tumor cells contributes to tumor progression; its mechanism, however, remains uncharacterized. We report in this work that injection of adenovirus expressing the human wild-type p53 gene (Ad5CMVp53) into… (More)

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@article{Waku2000ContributionOC, title={Contribution of CD95 ligand-induced neutrophil infiltration to the bystander effect in p53 gene therapy for human cancer.}, author={Toshihiko Waku and Toshiyoshi Fujiwara and Jieya Shao and Tatsuya Itoshima and Takuro N Murakami and Michihiko Kataoka and Shuichi Gomi and J A Roth and N Tanaka}, journal={Journal of immunology}, year={2000}, volume={165 10}, pages={5884-90} }