Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.

@article{Kim2008ContributionOC,
  title={Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys.},
  author={Eun-Young Kim and Ronald S Veazey and Roland Zahn and Kimberly J McEvers and Susanne H Baumeister and Gabriel J Foster and Melisa D. Rett and Michael H Newberg and Marcelo J. Kuroda and Ernst Peter Rieber and Michael J. Piatak and Jeffrey D Lifson and Norman L. Letvin and Steven M. Wolinsky and Joern E Schmitz},
  journal={Journal of virology},
  year={2008},
  volume={82 11},
  pages={5631-5}
}
Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation… CONTINUE READING
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