Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides

@inproceedings{Edwards2016ContributionOA,
  title={Contribution of Amphipathicity and Hydrophobicity
to the Antimicrobial Activity and Cytotoxicity of β-Hairpin
Peptides},
  author={Ingrid A. Edwards and Alysha G Elliott and Angela Maria Kavanagh and Johannes Zuegg and Mark A T Blaskovich and Matthew A. Cooper},
  booktitle={ACS infectious diseases},
  year={2016}
}
Bacteria have acquired extensive resistance mechanisms to protect themselves against antibiotic action. Today the bacterial membrane has become one of the "final frontiers" in the search for new compounds acting on novel targets to address the threat of multi-drug resistant (MDR) and XDR bacterial pathogens. β-Hairpin antimicrobial peptides are amphipathic, membrane-binding antibiotics that exhibit a broad range of activities against Gram-positive, Gram-negative, and fungal pathogens. However… CONTINUE READING
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Structure and Biological Functions of beta-Hairpin Antimicrobial Peptides

  • T. V. Ovchinnikova
  • Acta Nat
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