Contribution of ADAM33 polymorphisms to the population risk of asthma.

@article{Blakey2005ContributionOA,
  title={Contribution of ADAM33 polymorphisms to the population risk of asthma.},
  author={Julie Blakey and Eva Halapi and Unnur Steina Bjornsdottir and Anna Wheatley and Sigurður Kristinsson and Ruchi Upmanyu and K{\'a}ri Stef{\'a}nsson and Hakon Hakonarson and Ian P Hall},
  journal={Thorax},
  year={2005},
  volume={60 4},
  pages={274-6}
}
BACKGROUND ADAM 33 is the first gene identified as a candidate for asthma by positional cloning techniques, with association studies reaching impressive statistical significance. It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at… CONTINUE READING