Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.

Abstract

BACKGROUND AND PURPOSE The present study examined the contributions of a rise in cGMP versus a fall in 20-HETE levels to the vasodilator response to nitric oxide (NO) in the cerebral circulation of the rat. METHODS Intact rat middle cerebral and basilar arteries were bathed in physiological saline solution containing indomethacin (5 micromol/L) and… (More)

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