Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity.

@article{Maxwell2002ContrastingTR,
  title={Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity.},
  author={Joseph R. Maxwell and Carl E. Ruby and Nancy I Kerkvliet and Anthony T. Vella},
  journal={Journal of immunology},
  year={2002},
  volume={168 9},
  pages={4372-81}
}
The requirements for circumventing tolerance induction in favor of memory T cell development are poorly understood. Although two signals (Ag and costimulation) are necessary to drive effective T cell clonal expansion, few memory T cells remain after the response wanes. The adjuvant LPS can increase numbers of long-lived Ag-specific T cells, but its mechanism of action is not understood. In this report, it is shown that LPS, when combined with two-signal stimulation, profoundly enhances T cell… CONTINUE READING

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