Contrasting roles of complement activation and its regulation in membranous nephropathy.

  title={Contrasting roles of complement activation and its regulation in membranous nephropathy.},
  author={Patrick N. Cunningham and Richard J Quigg},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={16 5},
The complement system is involved in defense against microorganisms, the processing of immune complexes and apoptotic debris, and the development of an appropriate immune response. Along with these physiologic effects, complement activation has the potential to result in tissue pathology. To limit this, various complement regulatory proteins (CRP) are present on host cells, including the glomerular podocyte. Experimental data from the Heymann nephritis (HN) rat model of human membranous… CONTINUE READING


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