Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice.

@article{Couse2001ContrastingPI,
  title={Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice.},
  author={John F. Couse and Kenneth S. Korach},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={948},
  pages={1-8}
}
The estrogen receptor (ER) exists in two known forms, ERalpha and ERbeta, and acts as a ligand-inducible transcription factor to fulfill critical roles in reproductive physiology. Although in vitro studies suggest the ERs may play redundant roles, a dissimilar tissue distribution indicates otherwise. Therefore, to gain insight into the role of each ER form, individual lines of mice lacking each respective receptor, as well as mice lacking both ER forms, were generated. alphaERKO and betaERKO… CONTINUE READING
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