Contrasting patterns of selection acting on MHC class I and class II DRB genes in the Alpine marmot (Marmota marmota).

@article{Kuduk2012ContrastingPO,
  title={Contrasting patterns of selection acting on MHC class I and class II DRB genes in the Alpine marmot (Marmota marmota).},
  author={Katarzyna Kuduk and Aur{\'e}lie Johanet and Dominique Allain{\'e} and Aur{\'e}lie Cohas and Jacek Radwan},
  journal={Journal of evolutionary biology},
  year={2012},
  volume={25 8},
  pages={
          1686-93
        }
}
The major histocompatibility complex (MHC) genes code for proteins that play a critical role in the immune system response. The MHC genes are among the most polymorphic genes in vertebrates, presumably due to balancing selection. The two MHC classes appear to differ in the rate of evolution, but the reasons for this variation are not well understood. Here, we investigate the level of polymorphism and the evolution of sequences that code for the peptide-binding regions of MHC class I and class… CONTINUE READING

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