Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations

  title={Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations},
  author={D. Behar and D. Garrigan and M. E. Kaplan and Z. Mobasher and D. Rosengarten and T. Karafet and L. Quintana-Murci and H. Ostrer and K. Skorecki and M. Hammer},
  journal={Human Genetics},
  • D. Behar, D. Garrigan, +7 authors M. Hammer
  • Published 2003
  • Biology, Medicine
  • Human Genetics
  • The molecular basis of more than 25 genetic diseases has been described in Ashkenazi Jewish populations. Most of these diseases are characterized by one or two major founder mutations that are present in the Ashkenazi population at elevated frequencies. One explanation for this preponderance of recessive diseases is accentuated genetic drift resulting from a series of dispersals to and within Europe, endogamy, and/or recent rapid population growth. However, a clear picture of the manner in… CONTINUE READING
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