Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

@article{Vanderweyde2012ContrastingPO,
  title={Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.},
  author={Tara E Vanderweyde and Haung Yu and Megan Varnum and Liqun Liu-Yesucevitz and Allison Citro and Tsuneya Ikezu and Karen E Duff and Benjamin Wolozin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 24},
  pages={8270-83}
}
Stress induces aggregation of RNA-binding proteins to form inclusions, termed stress granules (SGs). Recent evidence suggests that SG proteins also colocalize with neuropathological structures, but whether this occurs in Alzheimer's disease is unknown. We examined the relationship between SG proteins and neuropathology in brain tissue from P301L Tau transgenic mice, as well as in cases of Alzheimer's disease and FTDP-17. The pattern of SG pathology differs dramatically based on the RNA-binding… CONTINUE READING
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