Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat
@article{Millan1999ContrastingMO, title={Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat}, author={Mark J Millan and Mauricette Brocco and Alain P. Gobert and F. Joly and Karin J. W. Bervoets and Jean Michel Rivet and Adrian Newman-Tancredi and Valérie Audinot and Sophie Maurel}, journal={European Journal of Neuroscience}, year={1999}, volume={11} }
In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP‐induced locomotion (PLOC) was potently blocked by the selective serotonin (5‐HT)2A vs. D2 antagonists, SR46349, MDL100,907, ritanserin and fananserin, which barely affected amphetamine‐induced locomotion (ALOC). In contrast, the selective D2 vs. 5‐HT2A antagonists, eticlopride, raclopride and amisulpride, preferentially inhibited…
139 Citations
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
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The results suggest that the effects of NRA0045 on PCP-induced abnormal behavior are similar to those of the atypical antipsychotic clozapine, and this inhibition may be mediated via the blockade of 5-HT2A receptors.
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Data support the contention that 5-HT1A receptor activation greatly reduces or prevents the cataleptogenic potential of novel antipsychotics, and emphasize that interactions at 5- HT1A and D2 receptors, and the nature of effects at the latter has a profound influence on pharmacological activities, and is likely to affect therapeutic profiles.
S 33084 , a Novel , Potent , Selective , and Competitive Antagonist at Dopamine D 3-Receptors : II . Functional and Behavioral Profile Compared with GR 218 , 231 and L 741 , 626
- Biology, Psychology
- 2000
A novel benzopyranopyrrole, S33084, that behaves as a potent, competitive, and selective (.100-fold) antagonist at cloned, human and native rat D3versus hD2-receptors (Table 1), and which shows only negligible lower affinity for all other sites examined to date.
Role of serotonin2A receptors in the d‐amphetamine‐induced release of dopamine: comparison with previous data on α1b‐adrenergic receptors
- Biology, Psychology
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It is proposed that 5‐HT2A and α1b‐adrenergic receptors control a common neural pathway responsible for the release of dopamine in the nucleus accumbens by psychostimulants.
5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum
- Biology, ChemistryNeuropsychopharmacology
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Combined serotonin (5-HT)1A agonism, 5-HT2A and dopamine D2 receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats
- Psychology, BiologyBehavioural Brain Research
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Prevention of the Phencyclidine-Induced Impairment in Novel Object Recognition in Female Rats by Co-Administration of Lurasidone or Tandospirone, a 5-HT1A Partial Agonist
- Biology, PsychologyNeuropsychopharmacology
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The ability of lurasidone co-treatment to prevent the PCP-induced NOR deficit was enduring and still present at day 22, further evidence for the importance of 5-HT1A receptor stimulation in the NOR deficit produced by subchronic PCP.
Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses
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Compared locomotor responses to PCP and MK-801 in rats that were administered 5,7-dihydroxytryptamine into either the dorsal or ventral hippocampus are compared, which has implications for studies utilizing NMDA receptor antagonists in modeling glutamatergic dysfunction in schizophrenia.
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The locomotor response to SSRIs of mice exposed to a novel environment is mediated via 5-HT1B and5-HT2A receptors, and the significance of these observations to the clinical actions ofSSRIs will be of interest to elucidate.
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