Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat

@article{Millan1999ContrastingMO,
  title={Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat},
  author={M. Millan and M. Brocco and A. Gobert and F. Joly and K. Bervoets and J. Rivet and A. Newman-Tancredi and V. Audinot and S. Maurel},
  journal={European Journal of Neuroscience},
  year={1999},
  volume={11}
}
In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP‐induced locomotion (PLOC) was potently blocked by the selective serotonin (5‐HT)2A vs. D2 antagonists, SR46349, MDL100,907, ritanserin and fananserin, which barely affected amphetamine‐induced locomotion (ALOC). In contrast, the selective D2 vs. 5‐HT2A antagonists, eticlopride, raclopride and amisulpride, preferentially inhibited… Expand
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TLDR
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TLDR
The results suggest that the effects of NRA0045 on PCP-induced abnormal behavior are similar to those of the atypical antipsychotic clozapine, and this inhibition may be mediated via the blockade of 5-HT2A receptors. Expand
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TLDR
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S 33084 , a Novel , Potent , Selective , and Competitive Antagonist at Dopamine D 3-Receptors : II . Functional and Behavioral Profile Compared with GR 218 , 231 and L 741 , 626
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Role of serotonin2A receptors in the d‐amphetamine‐induced release of dopamine: comparison with previous data on α1b‐adrenergic receptors
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TLDR
This triple combination of 5- HT(1A) agonism, 5-HT(2A) antagonism/inverse agonism and D2 antagonism is able to mimic the ability of atypical APDs to prevent or ameliorate the PCP-induced NOR deficit. Expand
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TLDR
The ability of lurasidone co-treatment to prevent the PCP-induced NOR deficit was enduring and still present at day 22, further evidence for the importance of 5-HT1A receptor stimulation in the NOR deficit produced by subchronic PCP. Expand
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TLDR
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TLDR
The locomotor response to SSRIs of mice exposed to a novel environment is mediated via 5-HT1B and5-HT2A receptors, and the significance of these observations to the clinical actions ofSSRIs will be of interest to elucidate. Expand
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