Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat

@article{Millan1999ContrastingMO,
  title={Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat},
  author={M. Millan and M. Brocco and A. Gobert and F. Joly and K. Bervoets and J. Rivet and A. Newman-Tancredi and V. Audinot and S. Maurel},
  journal={European Journal of Neuroscience},
  year={1999},
  volume={11}
}
In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP‐induced locomotion (PLOC) was potently blocked by the selective serotonin (5‐HT)2A vs. D2 antagonists, SR46349, MDL100,907, ritanserin and fananserin, which barely affected amphetamine‐induced locomotion (ALOC). In contrast, the selective D2 vs. 5‐HT2A antagonists, eticlopride, raclopride and amisulpride, preferentially inhibited… Expand
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S 33084 , a Novel , Potent , Selective , and Competitive Antagonist at Dopamine D 3-Receptors : II . Functional and Behavioral Profile Compared with GR 218 , 231 and L 741 , 626
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d‐Amphetamine is known to induce an increase in dopamine release in subcortical structures, thus inducing locomotor hyperactivity in rodents. Previous data have indicated that only 15% of theExpand
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The results show that 5-HT2A and 5- HT2C receptors regulate specifically the activation of midbrain DA neurons induced by amphetamine and morphine, respectively, and suggest that 4-HT1C receptors selectively modulate the impulse flow–dependent release of DA. Expand
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TLDR
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TLDR
The locomotor response to SSRIs of mice exposed to a novel environment is mediated via 5-HT1B and5-HT2A receptors, and the significance of these observations to the clinical actions ofSSRIs will be of interest to elucidate. Expand
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