Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat

@article{Millan1999ContrastingMO,
  title={Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5‐HT2A sites for PCP‐induced locomotion in the rat},
  author={Mark J Millan and Mauricette Brocco and Alain P. Gobert and F. Joly and Karin J. W. Bervoets and Jean Michel Rivet and Adrian Newman-Tancredi and Valérie Audinot and Sophie Maurel},
  journal={European Journal of Neuroscience},
  year={1999},
  volume={11}
}
In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP‐induced locomotion (PLOC) was potently blocked by the selective serotonin (5‐HT)2A vs. D2 antagonists, SR46349, MDL100,907, ritanserin and fananserin, which barely affected amphetamine‐induced locomotion (ALOC). In contrast, the selective D2 vs. 5‐HT2A antagonists, eticlopride, raclopride and amisulpride, preferentially inhibited… 
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TLDR
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TLDR
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TLDR
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TLDR
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