Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.

@article{Ito2016ContrastingIA,
  title={Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.},
  author={Fumiya Ito and Takahiro Nishiyama and Lei Shi and Masahiko Mori and Tasuku Hirayama and Hideko Nagasawa and Hiroyuki Yasui and Shinya Toyokuni},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={476 4},
  pages={
          600-606
        }
}
Iron is an essential nutrient for every type of life on earth. However, excess iron is cytotoxic and can lead to an increased cancer risk in humans. Catalytic ferrous iron [Fe(II)] is an initiator of the Fenton reaction, which causes oxidative stress by generating hydroxyl radicals. Recently, it became possible to localize catalytic Fe(II) in situ with a turn-on fluorescent probe, RhoNox-1. Here, we screened each organ/cell of rats to globally evaluate the distribution of catalytic Fe(II) and… CONTINUE READING
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