Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice.

@article{Smith1987ContrastingII,
  title={Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice.},
  author={Susan M Smith and Colleen Hayes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 16},
  pages={
          5878-82
        }
}
Mice fed a semipurified, vitamin A-deficient diet (A- mice) and control animals fed the same diet with added retinyl acetate (A+ mice) were used to investigate the effect of vitamin A deficiency on primary immunoglobulin responses to protein antigens. At age 6 weeks, A- mice had serum retinol concentrations that were 46% of A+ controls. When immunized with a single antigen dose, these mice produced an antigen-specific IgM response equivalent to controls, but their IgG1 and IgG3 responses were… CONTINUE READING

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