Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control.

@article{Molinari2004ContrastingFO,
  title={Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control.},
  author={Maurizio Molinari and Klara Kristin Eriksson and Verena Calanca and Carmela Galli and Peter Cresswell and Marek Michalak and Ari Helenius},
  journal={Molecular cell},
  year={2004},
  volume={13 1},
  pages={125-35}
}
Calreticulin and calnexin are homologous lectins that serve as molecular chaperones for glycoproteins in the endoplasmic reticulum of eukaryotic cells. Here we show that calreticulin depletion specifically accelerates the maturation of cellular and viral glycoproteins with a modest decrease in folding efficiency. Calnexin depletion prevents proper maturation of some proteins such as influenza hemagglutinin but does not interfere appreciably with the maturation of several others. A dramatic loss… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Recovery of Yeast Saccharomyces cerevisiae after Thermal Insult

A L Hänninen, Docent Sirkka Keränen, Docent Matti Korhola
2010
View 3 Excerpts
Highly Influenced

Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics.

Progress in molecular biology and translational science • 2016

Similar Papers

Loading similar papers…