Contrasting forms of cocaine-evoked plasticity control components of relapse

@article{Pascoli2014ContrastingFO,
  title={Contrasting forms of cocaine-evoked plasticity control components of relapse},
  author={Vincent Pascoli and Jean Terrier and Julie Espallergues and Emmanuel Valjent and Eoin Cornelius O’Connor and Christian L{\"u}scher},
  journal={Nature},
  year={2014},
  volume={509},
  pages={459-464}
}
Nucleus accumbens neurons serve to integrate information from cortical and limbic regions to direct behaviour. Addictive drugs are proposed to hijack this system, enabling drug-associated cues to trigger relapse to drug seeking. However, the connections affected and proof of causality remain to be established. Here we use a mouse model of delayed cue-associated cocaine seeking with ex vivo electrophysiology in optogenetically delineated circuits. We find that seeking correlates with rectifying… CONTINUE READING
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