Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man.

@article{Maxwell1987ContrastingEO,
  title={Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man.},
  author={D. Maxwell and R. Fuller and T. Conradson and C. Dixon and V. Aber and J. Hughes and P. Barnes},
  journal={Acta physiologica Scandinavica},
  year={1987},
  volume={131 3},
  pages={
          459-65
        }
}
  • D. Maxwell, R. Fuller, +4 authors P. Barnes
  • Published 1987
  • Chemistry, Medicine
  • Acta physiologica Scandinavica
  • Six normal male subjects, ages 28-40 years, were studied on separate days during increasing infusions with adenosine, 40-120 micrograms kg-1 min-1, before and during infusions of two xanthine derivatives, theophylline (mean plasma concentration 9 mg l-1) and enprofylline (mean plasma concentration 3 mg l-1). The study was double-blind, randomized, placebo controlled. Cardio-respiratory variables were measured non-invasively. Adenosine by itself increased heart rate (P less than 0.05), skin… CONTINUE READING
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