Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis.

@article{Ikezumi2010ContrastingEO,
  title={Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis.},
  author={Yohei Ikezumi and Toshiaki Suzuki and Tamaki Karasawa and Hiroya Hasegawa and Hiroshi Kawachi and David J Nikolic-Paterson and Makoto Uchiyama},
  journal={American journal of nephrology},
  year={2010},
  volume={31 3},
  pages={273-82}
}
BACKGROUND Macrophages with a pro-inflammatory (M1) phenotype mediate renal injury in proliferative forms of glomerulonephritis, while alternatively activated (M2) macrophages are thought to be anti-inflammatory and promote repair. Glucocorticoids, the mainstay therapy for proliferative glomerulonephritis, can induce alternative macrophage activation in vitro, but it is unknown whether this occurs in vivo and if this is required for glucocorticoid responsiveness. In addition, clinical studies… CONTINUE READING

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