Contrasting effects of selective T- and L-type calcium channel blockade on glomerular damage in DOCA hypertensive rats.

@article{Karam1999ContrastingEO,
  title={Contrasting effects of selective T- and L-type calcium channel blockade on glomerular damage in DOCA hypertensive rats.},
  author={Hanan N. Karam and J P Clozel and Patrick Bruneval and M Fernanda Gonz{\'a}lez and Jo{\"e}l M{\'e}nard},
  journal={Hypertension},
  year={1999},
  volume={34 4 Pt 1},
  pages={673-8}
}
Mibefradil and amlodipine are calcium antagonists with different channel selectivities. Mibefradil blocks both L- and T-type calcium channels; although in the usual pharmacological doses, it predominantly blocks the T-type channels. In contrast, amlodipine selectively blocks L-type channels. The goal of the present study was to assess whether this differential selectivity would result in different effects on end-organ damage in experimental hypertension. For this purpose, deoxycorticosterone… CONTINUE READING
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