Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.

@article{DoisneauSixou2003ContrastingEO,
  title={Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.},
  author={Sophie F. Doisneau-Sixou and Philippe Cestac and Sarah Chouini and Jason S. Carroll and Andrew D. Hamilton and Said M. Sebti and Marc Poirot and Patrick Balaguer and Jean-Charles Faye and Robert Lyndsay Sutherland and Gilles Favre},
  journal={Endocrinology},
  year={2003},
  volume={144 3},
  pages={989-98}
}
Activation of estrogen receptors (ERs) by estrogens triggers both ER nuclear transcriptional activity and Src/Ras/Erks pathway-dependent mitogenic activity. The present study implicates prenylated proteins in both estrogenic actions. The farnesyltransferase and geranylgeranyltransferase I inhibitors (FTI-277 and GGTI-298, respectively) antagonize estradiol-stimulated cell cycle progression, progesterone receptor, cyclin D1, and c-Myc expression. In contrast, the inhibitors markedly stimulate… CONTINUE READING

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