Contrasting effects of mitogenic growth factors on myelination in neuron-oligodendrocyte co-cultures.

@article{Wang2007ContrastingEO,
  title={Contrasting effects of mitogenic growth factors on myelination in neuron-oligodendrocyte co-cultures.},
  author={Zhen Wang and Holly Colognato and Charles ffrench-Constant},
  journal={Glia},
  year={2007},
  volume={55 5},
  pages={537-45}
}
Mitogenic growth factors play an important role in the initial stages of oligodendrocyte development, but their roles in the process of myelination itself remain less well defined. In order to study directly the effects of different growth factors on myelination, we used a purified in vitro co-culture system with dorsal root ganglion neurons and oligodendrocytes. Extensive myelination had occurred in these cultures 14 days after oligodendrocyte precursors (OPCs) were added, with the… CONTINUE READING
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