Contrasting effects of misoprostol on systemic and intrapulmonary lipopolysaccharide-induced tumor necrosis factor-alpha.

@article{Nakamura1992ContrastingEO,
  title={Contrasting effects of misoprostol on systemic and intrapulmonary lipopolysaccharide-induced tumor necrosis factor-alpha.},
  author={C Nakamura and Steve Nelson and Howard L. Lippton and Gregory J. Bagby and W. Summer},
  journal={Life sciences},
  year={1992},
  volume={50 24},
  pages={
          1869-76
        }
}
Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes
TLDR
Results indicate that misoprostol exerts anti-inflammatory effects on equine leukocytes when applied before or after a pro-inflammatory stimulus, and these effects were cytokine-specific and sometimes differed at the mRNA and protein levels.
Effects of the Prostaglandin Analogue Misoprostol on TNF-alpha Release by Activated Equine Leukocytes.
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The results presented in this study show that addition of LPS to equine leukocytes induced TNF-α secretion and misoprostol effectively blunted this response, suggesting misop frostol may be useful as an immunomodulator of inflammatory cytokine production in SIRS/sepsis.
Misoprostol Therapeutics Revisited
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Misoprostol enhances glycosoaminoglycan synthesis in cartilage after injury and reduces intraocular pressure in glaucoma and ocular hypertension, and reduces chemotherapy‐induced hair loss and recovery time from burn injury.
Novel applications of misoprostol.
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  • Medicine, Biology
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  • 1995
Treatment of canine atopic dermatitis with misoprostol, a prostaglandin E1 analogue: an open study
TLDR
The present study suggests that LPR inhibitors may be effective in canine AD, and this results need to be confirmed in future studies.

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