Contrasting effects of ischemia on the kinetics of membrane voltage and intracellular calcium transient underlie electrical alternans.

@article{Lakireddy2005ContrastingEO,
  title={Contrasting effects of ischemia on the kinetics of membrane voltage and intracellular calcium transient underlie electrical alternans.},
  author={Vikram Lakireddy and Paramdeep S Baweja and Asma Syed and Gil Bub and Mohamed Boutjdir and Nabil El-Sherif},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 1},
  pages={H400-7}
}
Repolarization alternans has been considered a strong marker of electrical instability. The objective of this study was to investigate the hypothesis that ischemia-induced contrasting effects on the kinetics of membrane voltage and intracellular calcium transient (Ca(i)T) can explain the vulnerability of the ischemic heart to repolarization alternans. Ischemia-induced changes in action potential (AP) and Ca(i)T resulting in alternans were investigated in perfused Langendorff guinea pig hearts… CONTINUE READING
20 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Dynamic restitution of action potential duration in dogs cardiac fibers

  • ML Koller, ML Riccio, RF Jr.Gilmour
  • Am J Physiol Heart Circ Physiol 275:
  • 1998
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…