Contrasting effects of hyperoxia on GM-CSF gene transcription in alveolar epithelial cells and T cells

@inproceedings{Sturrock2015ContrastingEO,
  title={Contrasting effects of hyperoxia on GM-CSF gene transcription in alveolar epithelial cells and T cells},
  author={Anne Sturrock and Jessica C. A. Baker and Mustafa Mir-Kasimov and Robert Paine},
  booktitle={Physiological reports},
  year={2015}
}
Granulocyte/macrophage colony-stimulating factor (GM-CSF) is critically important for normal pulmonary innate immunity and for functional maturation of alveolar macrophages. Alveolar epithelial cells (AEC) are a major source of GM-CSF in the lung and express this growth factor constitutively, whereas most other cells, including T cells, express GM-CSF following inflammatory stimulation. AEC expression of GM-CSF is suppressed by oxidative stress, at least in part through induction of microRNA… CONTINUE READING
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