Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.

@article{Neschen2002ContrastingEO,
  title={Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.},
  author={Susanne Neschen and Irene C. Moore and Werner Regittnig and Chun Li Yu and Yanlin Wang and Marc Pypaert and Kitt Falk Petersen and Gerald I Shulman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 2},
  pages={E395-401}
}
To examine the mechanism by which fish oil protects against fat-induced insulin resistance, we studied the effects of control, fish oil, and safflower oil diets on peroxisomal content, fatty acyl-CoA, diacylglycerol, and ceramide content in rat liver and muscle. We found that, in contrast to control and safflower oil-fed rats, fish oil feeding induced a 150% increase in the abundance of peroxisomal acyl-CoA oxidase and 3-ketoacyl-CoA thiolase in liver but lacked similar effects in muscle. This… CONTINUE READING

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