Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.

@article{Ye2009ContrastingEO,
  title={Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.},
  author={Ping Ye and Tetsuji Yamashita and David M Pollock and Hironobu Sasano and William E. Rainey},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2009},
  volume={41 1},
  pages={35-9}
}
Spironolactone and eplerenone are widely used as mineralocorticoid antagonists. Spironolactone has several nonspecific actions including inhibition of androgen receptor and steroid hormone biosynthesis. While studies have shown that eplerenone does not exhibit nonspecific actions on androgen receptor, its effects on steroid hormone production have not been reported. Herein, the effects of eplerenone (0.1-30 microM) and spironolactone (0.1-30 microM) on steroid production were examined in human… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…