Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction.

@article{Bahtiyar2007ContrastingEO,
  title={Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction.},
  author={Mert Ozan Bahtiyar and Catalin Sorin Buhimschi and Viswanathan Ravishankar and Joshua Copel and Errol R. Norwitz and Svena Julien and S. A. Guller and Irina Alexandra Buhimschi},
  journal={American journal of obstetrics and gynecology},
  year={2007},
  volume={196 1},
  pages={72.e1-6}
}
OBJECTIVE We hypothesized that nitric oxide (NO) inhibition has synergistic effects with chronic hypoxia in altering maternal serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), vascular endothelial growth factor (VEGF), and placental growth factor (PlGF). We tested our hypothesis in a rodent model of intrauterine growth restriction induced by chronic hypoxia and NO inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME). STUDY DESIGN Timed pregnant adult Sprague-Dawley rats were… CONTINUE READING

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