Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure.

@article{Harada2002ContrastingEO,
  title={Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure.},
  author={Sanae Harada and Tetsuo Nakata and Atsuhiko Oguni and Hidenori Kido and Tsuguru Hatta and Ryuichi Fukuyama and Shinji Fushiki and Susumu Sasaki and Kazuo Takeda},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2002},
  volume={25 5},
  pages={779-86}
}
This study was designed to test the hypothesis that increased pressure itself could cause endothelial dysfunction and lead to decreased nitric oxide (NO) release, partly through effects on the tissue renin angiotensin system in hypertension. Cultured endothelial cells (ECs) isolated from the aortas of WKY rats were continuously exposed to a pressure of 150 mmHg in a CO2 incubator for 72 h using a pressure system, and the NOx (NO2 and NO3) and angiotensin II (Ang II) concentrations in the… CONTINUE READING

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Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow.

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References

Publications referenced by this paper.
Showing 1-10 of 40 references

Lowering of blood pressure improves endothelial dysfunction by increase of nitric oxide production in hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension • 2002
View 1 Excerpt

An angiotensin II type 1 receptor blocker, candesartan, increases myocardial apoptosis in rats with acute ischemia-reperfusion.

Hypertension research : official journal of the Japanese Society of Hypertension • 2001
View 1 Excerpt

and cardiovascular risk factors : role of the angiotensin II - nitric oxide interaction

T Nakata, K Takeda, S Harada
2001

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