Contrasting effects of a gonadotropin-releasing hormone agonist and antagonist on the secretion of free alpha subunit.

Gonadotropin-releasing hormone agonists and antagonists have initial divergent effects on the pituitary secretion of intact biologically active gonadotropins and long-term divergent effects on the secretion of free alpha-subunit. The antagonists appear to function as true competitive inhibitors, blocking the stimulatory effects of endogenous GnRH without… CONTINUE READING