Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanisms.

@article{Kim2010ContrastingAO,
  title={Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanisms.},
  author={Jie-Hyun Kim and Hyun S. Shin and Sang Hun Lee and Inohk Lee and Yeo Song Lee and Jun Chul Park and Yu Jin Kim and Jae Bock Chung and Yong Chan Lee},
  journal={Cancer science},
  year={2010},
  volume={101 2},
  pages={328-35}
}
Gastric cancer displays different biological behaviors according to histological differentiation. The different biological behavior might involve the activation of distinct signaling pathways necessary for the growth and survival of cancer cells in gastric cancer. We investigated the differentiation-related signal interaction between Hedgehog and Wnt pathways in gastric cancer cells. Differentiation of gastric cancer cells was induced by sodium butyrate. The sonic Hedgehog (SHH) signal… CONTINUE READING

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