Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.

@article{Brier2003ContrastingAO,
  title={Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.},
  author={Tim J Brier and Ian R. Mellor and Denis B. Tikhonov and Ioana Neagoe and Zuoyi Shao and Matt J Brierley and Kristian Str\omgaard and Jerzy W. Jaroszewski and Povl Krogsgaard-Larsen and Peter N. R. Usherwood},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 4},
  pages={954-64}
}
Whole-cell recordings and outside-out patch recordings from TE671 cells were made to investigate antagonism of human muscle nicotinic acetylcholine receptors (nAChR) by the philanthotoxins, PhTX-343 and PhTX-(12). When coapplied with acetylcholine (ACh), PhTX-343 caused activation-dependent, noncompetitive inhibition (IC50 = 17 microM at -100 mV) of whole-cell currents that was strongly voltage-dependent. However, preapplication of PhTX-343 unveiled a voltage-independent antagonism that also… CONTINUE READING

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Allosteric and steric interactions of polyamines and polyamine-containing toxins with nicotinic acetylcholine receptors, in Perspectives in Molecular Toxinology (Ménez A ed) pp 281–297

  • TJ Brier, IR Mellor, PNR Usherwood
  • 2002
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