Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice.

Abstract

BACKGROUND Interleukin (IL)-12 and IL-18 are major interferon (IFN)-gamma-inducing factors that collaborate with each other. The present study was conducted to determine the distinct roles of IL-12 and IL-18 in the development of dextran sulphate sodium (DSS) colitis in mice. METHODS Colitis was induced in IL-12p35(-/-), IL-18(-/-), IL-18 receptor… (More)

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