Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

@article{Achterberg2016ContrastingRO,
  title={Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats},
  author={E. J. Marijke Achterberg and L.W.M. van Kerkhof and Michela Servadio and M. M. H. van Swieten and Danielle J. Houwing and Mandy Aalderink and Nina V Driel and Viviana Trezza and Louk J.M.J. Vanderschuren},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={858-868}
}
Social play behavior, abundant in the young of most mammalian species, is thought to be important for social and cognitive development. Social play is highly rewarding, and as such, the expression of social play depends on its pleasurable and motivational properties. Since the motivational properties of social play have only sporadically been investigated, we developed a setup in which rats responded for social play under a progressive ratio schedule of reinforcement. Dopaminergic… 
Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats
TLDR
Functional activity in the mesolimbic dopamine pathway plays an important role in adaptive social development, whereas abnormal NAc dopamine function may underlie the social impairments observed in developmental psychiatric disorders such as autism, attention deficit hyperactivity disorder or early-onset schizophrenia.
The neurobiology of social play and its rewarding value in rats
TLDR
In sum, social play behaviour is the result of coordinated activity in a network of corticolimbic structures, and its monoamine, opioid and endocannabinoid innervation.
Opioid modulation of social play reward in juvenile rats
TLDR
The data implicate opioid neurotransmission in both the pleasurable and the motivational aspects of social play behaviour in rats, which is widely implicated in reward processes.
Dissociating the role of endocannabinoids in the pleasurable and motivational properties of social play behaviour in rats.
TLDR
Data demonstrate that enhancing endocannabinoid levels does not differentially affect the motivational and pleasurable aspects of social play behaviour, whereas CB1 receptor blockade reduces the motivational aspects of Social Play behaviour, possibly due to response competition.
Treatment with low doses of nicotine but not alcohol affects social play reward in rats
ABSTRACT Social play behaviour is a vigorous, highly rewarding activity in young animals. It is thought to facilitate social, cognitive and emotional development, but its underlying neural mechanisms
Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats
TLDR
It is found that exposure to social play increased recruitment of ORX-A neurons in juvenile rats and provided the first evidence of a role for the ORX system in the modulation of juvenile social play behaviour.
On the central noradrenergic mechanism underlying the social play-suppressant effect of methylphenidate in rats
TLDR
There is redundancy in the neural circuitry that mediates the play‐suppressant effect of methylphenidate, whereby prefrontal cortical and subcortical limbic mechanisms act in parallel, and the notion that prefrontal noradrenergic mechanisms contribute to the locomotor enhancing effect of psychostimulant drugs is supported.
Role of oxytocin in the ventral tegmental area in social reinforcement
TLDR
The hypothesis that activation of OT receptors in the VTA are critical for the reinforcing properties of social interactions is supported, as social interactions may exhibit duration and cost dependent reinforcing effects on behavior similar to those observed with food and drugs of abuse.
Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin
TLDR
A mechanism by which the LS-AVP system alters LS-DA neurotransmission differently in males than females resulting in the sex-specific regulation of juvenile social play behavior is defined.
Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play
TLDR
Behavioral, pharmacological, electrophysiological, and genetic approaches are combined to elucidate the role of the endocannabinoid 2-arachidonoylglycerol (2-AG) in social play, and how cannabinoid and opioid neurotransmission interact to control social behavior in adolescent rodents, and shed new light on the mechanism by which endoc cannabinoidoid lipids and opioid peptides interact to orchestrate rodent socioemotional behaviors.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 64 REFERENCES
Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms
TLDR
Investigating the pharmacological underpinnings of amphetamine- and cocaine-induced suppression of social play behavior in rats contributes to the understanding of the neural mechanisms of social behavior during an important developmental period, and of the deleterious effects of psychostimulant exposure thereon.
Methylphenidate and Atomoxetine Inhibit Social Play Behavior through Prefrontal and Subcortical Limbic Mechanisms in Rats
TLDR
The data show that the inhibitory effects of methylphenidate and atomoxetine on social play are mediated through a distributed network of prefrontal and limbic subcortical regions implicated in cognitive control and emotional processes.
The pleasures of play: pharmacological insights into social reward mechanisms.
TLDR
This review addresses the notion that social play is rewarding, and discusses recent developments in the neuropharmacology of this behavior, which provides a framework to understand how the brain processes social emotions, to make young individuals enjoy social play.
The neurobiology of social play behavior in rats
TLDR
There is not only behavioral, but also neurobiological evidence to suggest that social play behavior represents a separate category of behavior, instead of a precursor for adult social, sexual or aggressive behavior.
Effects of morphine on different aspects of social play in juvenile rats
TLDR
In juvenile rats playful and non-playful forms of social behavior are differentially regulated, and opioid systems may be involved at different levels in the regulation of social play.
Evaluating the rewarding nature of social interactions in laboratory animals
TLDR
It is shown that maternal behavior, social play and sexual interaction can be used as incentive for place conditioning, lever pressing and maze learning, three setups that have been extensively used to study the rewarding properties of food and drugs of abuse and their neural underpinnings.
Divergent Effects of Anandamide Transporter Inhibitors with Different Target Selectivity on Social Play Behavior in Adolescent Rats
TLDR
The notion that anandamide plays an important role in the modulation of social interaction in adolescent rats is supported, and it is suggested that selective an andamide transporter inhibitors might be useful for the treatment of social dysfunctions.
Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms
TLDR
The results show that the facilitatory effects of nicotine and ethanol on social play are behaviorally specific and mediated through neurotransmitter systems involved in positive emotions and motivation, through partially dissociable mechanisms.
Bidirectional cannabinoid modulation of social behavior in adolescent rats
TLDR
Results shed light on the paradoxical relationship between cannabis exposure and sociability and suggest that endocannabinoid degradation inhibitors hold promise for the treatment of social dysfunctions.
In search of the neurobiological substrates for social playfulness in mammalian brains
TLDR
How increased insights into the neurobiological mechanisms of play can inform the understanding of normal and abnormal childhood development is discussed.
...
1
2
3
4
5
...