Contrasting Localizations of MALS/LIN-7 PDZ Proteins in Brain and Molecular Compensation in Knockout Mice*

@article{Misawa2001ContrastingLO,
  title={Contrasting Localizations of MALS/LIN-7 PDZ Proteins in Brain and Molecular Compensation in Knockout Mice*},
  author={H. Misawa and Y. Kawasaki and J. Mellor and N. Sweeney and K. Jo and R. Nicoll and D. Bredt},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={9264 - 9272}
}
Proteins containing PDZ (postsynaptic density-95, discs large, zonula occludens) domains play a general role in recruiting receptors and enzymes to specific synaptic sites. In Caenorhabditis elegans, a complex of three PDZ proteins, LIN-2/7/10, mediates basolateral targeting of a receptor tyrosine kinase. Homologs of these LIN proteins have also been identified in higher organisms, and here we analyze the MALS/Veli (mammalianLIN-7/vertebrate homolog of LIN-7) proteins in brain… Expand
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Disparate cell types use a shared complex of PDZ proteins for polarized protein localization.
  • C. Rongo
  • Biology, Medicine
  • Cytokine & growth factor reviews
  • 2001
Role of an adaptor protein Lin‐7B in brain development: possible involvement in autism spectrum disorders
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